Anavar is not known to produce tremendous gains in muscle mass at the dosages most users ingest, it does however possess a reputation for burning fat and giving the body a more cut look. Additionally, the muscle mass gained and fat burned tend to be more permanent than with the steroids associated with large muscle mass gains. Anavar is considered one of the safest steroids available in terms of side effect profile. Although it is C-17 alkylated, it has actually been shown to improve liver function over time, and negative feedback on the body’s production of endogenous sex hormones is far less pronounc ed than with most other compounds.
Anavar was the original U.S. brand name for the oral steroid oxandrolone, first produced in 1964 by the drug manufacturer Searle. It was designed to be an extremely mild anabolic, one that could be used safely as a growth stimulant in children. Steroids are usually known to stunt growth primarily due to excess estrogen or estrogen metabolites affecting the epiphyseal plates of long bones. The same hormonal mechanism is the reason why women stop growing sooner and have a shorter average height than men. Oxandrolone will not aromatize into estrogen, therefore the anabolic effect of the compound can actually promote linear growth. Women usually tolerate this drug well at low doses, and at one time it was prescribed for the treatment of osteoporosis in women. As the opinions surrounding steroids began to change in the 1980′s, prescriptions for oxandrolone began to drop. Lagging sales led Searle to discontinue manufacturing Anavar in 1989, and it has vanished from U.S. pharmacies until recently. Oxandrolone tablets are again available inside the U.S. by BTG, bearing the new brand name Oxandrin. BTG purchased rights to the drug from Searle and it is now manufactured for the new purpose of treating HIV/AIDS related wasting syndrome.
Anavar is a mild anabolic with low androgenic activity. Its androgenic activity is reduced because it is a derivative of dihydrotestosterone (DHT) and is already “5-alpha reduced.” In other words, it lacks the capacity to interact with the 5-alpha reductase enzyme and convert to a more potent “dihydro” form. Androgenic activity refers to binding affinity with androgenic receptors on target tissues. In essence, oxandrolone has a balanced level of potency in both muscle and androgenic tissues such as the scalp, skin, and prostate because it does not convert to a “dihydro” metabolite. The same is noted with both Primobolan and Winstrol, which are also derived from dihydrotestosterone yet not known to be very androgenic substances. Anabolic steroids such as these are therefore less powerful overall than their more androgenic counterparts but cause far fewer side effects and are targeted much more specifically to skeletal muscle growth.
Studies using low dosages of this compound noted minimal interferences with natural testosterone production. Likewise when it is used alone in small amounts there is typically no need for ancillary drugs like Clomid, Nolvadex, or HCG. This is primarily due to oxandrolone not converting to estrogen, which has an extremely profound effect on endogenous hormone production. Without estrogen triggering negative feedback, a higher threshold of dosage and cycle leng th is afforded to the athlete before inhibition occurs. However, at higher dosages, a suppression of natural testosterone levels will occur with this drug as with any anabolic/androgenic steroid over time, therefore post cycle therapy to restore the HPTA is required.
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